Which cities should an enchanter not ruin faction with?

[El-Hefe]

So I’ve been thinking it might be fun to kill guards in Neriak, or kill Gnomes in Sol A. But I’m worried that I might need to make use of those cities in the future.

What cities are absolutely necessary for an Enchanter to maintain his faction for? Am I going to make doing Sol Ro or Epic quests impossible for myself in the future if I’m hated in a few towns?

Thanks.