Two Issues

[Tunabros]

the hot keys/macros disappearing is a known issue atm

it will likely be fixed next patch

for the full screen part, I'm not too sure on that but could try to run on compatibility mode

[Kaezyr D`Shiv]

Maybe you can try this:

Check that the EQ folder is not in the Program files folder and that it has: "read only" UNCHECKED, also try to set for permissions and security enabled for all set to everyone.