Quote:
Originally Posted by Itchybottom
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staying hydrated is not going to help very much during or after intoxication; in other words, simply drinking water when you're in hepatic overload is not going to be sufficient
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#1 theres a huge difference between hepatic overload and intoxication, and neither one happens with the first drink or so. If you start hydrating at this point, you shouldn't have any issues with a hangover.
Quote:
Originally Posted by Itchybottom
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because the large intestine usually secretes water rather than absorbing it. MUCH too rapidly to have any gainful effect on your elevated gamma-glutamyltransferas (GGT) leakage from your hepatocytes (liver cells). Even oral re-hydration therapy is not sufficient after the fact and should be ingested BEFORE you decide to drink.
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Elevated GGT levels are causative of hangovers now? Stop the press! How do you know such things? Also why would your large intestine begin secreting water after a couple drinks? That doesn't seem to make any sense. If this was true, everyone who ever went to college would have at least one story of how they had to go to the ER because they had water shooting out of their asses, and that they almost died from F&E imbalance..
Quote:
Originally Posted by Itchybottom
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Juice is also a very BAD idea without dilution, unless of course you want super fun diarrhea along with your hang-over. It's too high osmolarity!
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Not gonna argue with this.. I've had too many Mai Tais and not enough diarrhea. I guess I'm lucky? Maybe I have a magic digestive system!!
Quote:
Originally Posted by Itchybottom
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Digressing, if it was just dehydration and glucose levels causing hang-over, an intravenous glucose solution would cure it within the hour -- but even when plasma osmolality is 285 mOsm/l for such a solution, the hang-over persists.
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You're ignoring the fact that the symptoms of a "hangover" are directly tied to fluid loss in the CNS rather than the general system of the body. Your brain gets pickled as the ETOH steals water, leaving salts. Of course fluids (at this late stage) would take some time to work, that system is fairly closed, and requires some time for the body to rehydrate.
Quote:
Originally Posted by Itchybottom
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When you're suffering from acute ethanol toxicity
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Are you using "acute ethanol toxicity" as a euphamism for "drunk" or what?
Quote:
Originally Posted by Itchybottom
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it is primarily due to your hepatocytes not being able to produce adequate enzymes (which can be shown by transaminases levels in most cases) to counter-act the net effect. It's not unlike getting too much exercise without adequate fuel, and rather than generating beneficial enzymes to filter the blood stream, it moves onto massive cholestatic liver enzyme production (GGT as mentioned earlier and alkaline phosphatase) which inflames the bile ducts causing a shit storm of bad renal activity -- leading to fun conditions like biliary cirrhosis.
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Getting drunk = cirrhosis now??
I think your liver will work just fine until you drink a half gallon of whiskey all at once or you spend several years drinking a pint of whiskey a day..
It produces everything it needs to produce, just might take a bit longer. Chronic ETOH abuse is really the bigger danger don't you think? I'm getting a bit of "the sky is falling" from your post man..
Quote:
Originally Posted by Itchybottom
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The real problem [in this case] with medicine, is rather than studying the affects that cause and reduce hang-over, medical science seeks to just make you avoid ethanol all together for front line diagnostics. There are quite a few ways of curing a hang-over through blood diagnostic and for example treating it like autoimmune hepatitis with intravenous ciprofloaxin, xifaxan and then paired with an additional diuretic if there is any portal hypertension from chronic abuse - but it's costly, monetarily and in the long term for your body (antibiotic resistance, for when you do finally get sick enough to die.)
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In all seriousness, please tell me how cipro affects autoimmune hepatitis in a positive manner.. I've heard a LOT about how cipro can CAUSE hepatitis, but nothing about how it cures it. Please explain.
Quote:
Originally Posted by Itchybottom
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TLDR advice:
If someone gets a hang-over from two "Four-Loko" beverages, it's really time to start evaluating your dietary and life choices. That is not a sufficient amount of alcohol by volume to affect a healthy person acutely, even paired with the caffeine content -- and even with chronic alcoholism, I'm going to go ahead and say its Hot Pocket post parents' basement disorder and you're chronically dehydrated to begin with. Stop eating 30+ grams sugar based carbohydrates, 3 grams of sodium per meal and sucking on Mountain Dew all day, you retarded bastards!
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True. True.
11-18-2010, 02:53 PM
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