Four Loko

[Somekid123]

Alcohol is already hard on your liver [Not saying stop, believe me I drink]... but I wonder how much worse these are with all that sugar shit that amps you up.

[Japan]

diuretics mixed with diuretics = massive hangover and liver damage

[SlankyLanky]

Originally Posted by Olacaten [You must be logged in to view images. Log in or Register.]

I love those things, i went and got 15 of them today because they get banned in washhington romarrow.

well god damn now going to oly isnt so appealing if i cant get my slammie on.

[Hasbinbad]

Originally Posted by Japan [You must be logged in to view images. Log in or Register.]

diuretics mixed with diuretics = massive hangover and liver damage

How do diuretics cause liver damage? Just from deficient fluid volume? I wasn't aware of diuretics being a big villain behind liver damage. I believe they are used to help treat several forms of liver disease or dysfunction as well.

If that's the case, drinking water eliminates both of those problems, as hangovers are also related to deficient fluid volume.

I make it a rule to drink an 8oz glass of water every time I consume one or two "drinks" of alcohol, especially when drinking heavily. The extra trips to the head are well worth it the next day.

[Japan]

Originally Posted by Hasbinbad [You must be logged in to view images. Log in or Register.]

How do diuretics cause liver damage? Just from deficient fluid volume? I wasn't aware of diuretics being a big villain behind liver damage. I believe they are used to help treat several forms of liver disease or dysfunction as well.

If that's the case, drinking water eliminates both of those problems, as hangovers are also related to deficient fluid volume.

acetaldehyde metabolism/excretion is dependent on osmolar gradients in the blood and nephron which can't be maintained during severe dehydration. Acetaldehyde isn't very stable; cleaning it up puts a heavy enough load on your liver without it floating around in there for a prolonged period of time reacting with shit.

Drinking water does help. So does eating something sugary (lack of glucose is typically the biggest bottleneck in ethanol metabolism). Yes, orange juice will protect you from cirrhosis.

[Itchybottom]

Dehydration IS a factor in hang-over (as Japan is talking about ethanol oxidizing to acetaldehyde), but it's not the entire picture, and also it has little to do with a diuretic effect damaging your liver. Diuretics are good in most cases for liver damage, to treat ascites (accumulation of fluids) that goes along with such a temporary (or more permanent) problem. Liver and kidney load actually triggers an anti-diuretic effect and most of the problem with hang-over (according to the more recent case studies) has been correlated to higher up the chain in the endocrine system involving free radicals and glycine levels. Correlation, isn't all that amusing though and it's hard to argue the point based on that merit. Hope someone soon publishes the cliff notes, because the god damn Wiley-Blackwell journals can be pretty dizzying in rhetoric.

As far as miracle cures, staying hydrated is not going to help very much during or after intoxication; in other words, simply drinking water when you're in hepatic overload is not going to be sufficient, because the large intestine usually secretes water rather than absorbing it. MUCH too rapidly to have any gainful effect on your elevated gamma-glutamyltransferas (GGT) leakage from your hepatocytes (liver cells). Even oral re-hydration therapy is not sufficient after the fact and should be ingested BEFORE you decide to drink.

Juice is also a very BAD idea without dilution, unless of course you want super fun diarrhea along with your hang-over. It's too high osmolarity!

Digressing, if it was just dehydration and glucose levels causing hang-over, an intravenous glucose solution would cure it within the hour -- but even when plasma osmolality is 285 mOsm/l for such a solution, the hang-over persists. When you're suffering from acute ethanol toxicity, it is primarily due to your hepatocytes not being able to produce adequate enzymes (which can be shown by transaminases levels in most cases) to counter-act the net effect. It's not unlike getting too much exercise without adequate fuel, and rather than generating beneficial enzymes to filter the blood stream, it moves onto massive cholestatic liver enzyme production (GGT as mentioned earlier and alkaline phosphatase) which inflames the bile ducts causing a shit storm of bad renal activity -- leading to fun conditions like biliary cirrhosis.

The real problem [in this case] with medicine, is rather than studying the affects that cause and reduce hang-over, medical science seeks to just make you avoid ethanol all together for front line diagnostics. There are quite a few ways of curing a hang-over through blood diagnostic and for example treating it like autoimmune hepatitis with intravenous ciprofloaxin, xifaxan and then paired with an additional diuretic if there is any portal hypertension from chronic abuse - but it's costly, monetarily and in the long term for your body (antibiotic resistance, for when you do finally get sick enough to die.)


TLDR advice:
If someone gets a hang-over from two "Four-Loko" beverages, it's really time to start evaluating your dietary and life choices. That is not a sufficient amount of alcohol by volume to affect a healthy person acutely, even paired with the caffeine content -- and even with chronic alcoholism, I'm going to go ahead and say its Hot Pocket post parents' basement disorder and you're chronically dehydrated to begin with. Stop eating 30+ grams sugar based carbohydrates, 3 grams of sodium per meal and sucking on Mountain Dew all day, you retarded bastards!

[Japan]

+rep

[Cyrano]

I had Four Loko for the first time last weekend before the UT game along with two beers in about a 2 hour period. Didn't have a hangover the next day.

[Ihealyou]

http://www.youtube.com/watch?v=KVWWre8tn_U

[Boggwin Bramblefoot]

I just drank about 10 of these and shot some Carfentanil as a chaser. How cool am I. [You must be logged in to view images. Log in or Register.] Maybe later ill smoke some Dimethyltryptamin and have a few more.