No, full screen ends in grief, often a black screen then if you return sometimes all the UI is stuffed. It makes sense I guess if you exceed the game's resolution - monitors weren't commonly this large in the early 2000s. I run at max resolution according to EQ Options, 1680 x 1050, which consumes about 80% of the iMac screen. This permits access to the iMac Desktop while medding with mail and browser in multiple windows at the same time.
It's all good so far with my Necro now at level 5!
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