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Old 05-04-2021, 01:09 PM
Cecily Cecily is offline
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Originally Posted by Toxigen [You must be logged in to view images. Log in or Register.]
heres a novel idea

dont get the vaccine and let your body do what its designed to do
It's your body that kills you. Systemic novel viral infection -> huge immune response -> inflammation in lungs -> can't breathe.
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Old 05-04-2021, 01:43 PM
Jimjam Jimjam is offline
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It's your body that kills you. Systemic novel viral infection -> huge immune response -> inflammation in lungs -> can't breathe.
Surely then, it would be like the Spanish Flu, where people with the 'best' immune systems were worst affected?
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Old 05-04-2021, 02:10 PM
Cecily Cecily is offline
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Surely then, it would be like the Spanish Flu, where people with the 'best' immune systems were worst affected?
Not necessarily. Covid inhibits type 1 interferon response and that's already impaired in the elderly.

https://www.nature.com/articles/s41591-020-01202-8

"A key feature of coronaviruses (MERS-CoV, SARS-CoV) is a capability to inhibit and delay the type I IFN response, leading to increased viral replication and severe immunopathology. Also, SARS-CoV-2 is able to inhibit the type I IFN responses in infected cells, leading to delayed or overall suppressed type I IFN responses49,50. This allows the virus to replicate and induce more tissue damage, and triggers a more exuberant immune response as the immune system struggles to limit viral replication and to manage dying and dead cells. Immune pathology continues as inflammatory cells flow into the lung and produce large amounts of proinflammatory cytokines, further escalating the situation (Fig. 1c). Such imbalanced immune responses, caused in part by the impaired early type I IFN responses, are the most likely determinant of the overall severity of acute COVID-19 (refs. 50,51,52,53). This is further emphasized by recent results from the COVID Human Genetic Effort54 (https://www.covidhge.com/), which found that inborn errors in the type I IFN pathway55, or the presence of neutralizing autoantibodies to type I IFNs56, were strongly over-represented among individuals who developed life-threatening COVID-19. Whether imbalanced or impaired innate responses also contribute to the development of other disease manifestations such as MIS-C and long COVID remains to be determined."
Last edited by Cecily; 05-04-2021 at 02:12 PM..
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Old 05-04-2021, 02:15 PM
HalflingSpergand HalflingSpergand is offline
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Originally Posted by Cecily [You must be logged in to view images. Log in or Register.]
Not necessarily. Covid inhibits type 1 interferon response and that's already impaired in the elderly.

https://www.nature.com/articles/s41591-020-01202-8

"A key feature of coronaviruses (MERS-CoV, SARS-CoV) is a capability to inhibit and delay the type I IFN response, leading to increased viral replication and severe immunopathology. Also, SARS-CoV-2 is able to inhibit the type I IFN responses in infected cells, leading to delayed or overall suppressed type I IFN responses49,50. This allows the virus to replicate and induce more tissue damage, and triggers a more exuberant immune response as the immune system struggles to limit viral replication and to manage dying and dead cells. Immune pathology continues as inflammatory cells flow into the lung and produce large amounts of proinflammatory cytokines, further escalating the situation (Fig. 1c). Such imbalanced immune responses, caused in part by the impaired early type I IFN responses, are the most likely determinant of the overall severity of acute COVID-19 (refs. 50,51,52,53). This is further emphasized by recent results from the COVID Human Genetic Effort54 (https://www.covidhge.com/), which found that inborn errors in the type I IFN pathway55, or the presence of neutralizing autoantibodies to type I IFNs56, were strongly over-represented among individuals who developed life-threatening COVID-19. Whether imbalanced or impaired innate responses also contribute to the development of other disease manifestations such as MIS-C and long COVID remains to be determined."
Stop regurgitarding you guys don't know shit
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Old 05-04-2021, 02:23 PM
Cecily Cecily is offline
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Originally Posted by HalflingSpergand [You must be logged in to view images. Log in or Register.]
Stop regurgitarding you guys don't know shit
Another interesting part of that article mentioned a review which did not find any statistical risk increase in immunocompromised patients for severe infections, which was a question I had earlier today. No, I literally don't know shit, but there's a lot of good information in that article.

Covid less risky to kids because kids are made to get sick. Their thymus spits out more naive t-cells, which get produced less and less as we age. Obese/old people/diabetics have a worse neutrophil to lymphocyte ratio. That's an indicator for low grade systemic infection and screws up the response to the infection.
Last edited by Cecily; 05-04-2021 at 02:31 PM..
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