All you are doing with the Nvidia and AMD scaling features is telling windows it's hard defined native resolution then setting a predetermine resolution and when the GPU sees that resolution it immediately takes over and does it's scaling instead of windows or the game. Then you go and turn off windows ability to scale the application entirely while running in SP3 capability mode in the shortcut settings and it eliminates the crashes entirely when switching back and forth assuming you are using correct affinity settings on your CPU. I haven't found much hiccups with setting it up that way and I been playing p99 for quite some time.
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