one big one -- NPCs don't drop items you give them, so no charming mobs, giving them weapons with good procs and getting them back later!
I wasn't a big pet user in classic but I've been told classically they would take on delay of any weapons given, so you could give pets low delay weapons and speed them up. Don't know if it's true or if this was also nerfed classically but it's certainly not true here. Maybe someone who does remember can flesh this one out
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-Propo Fol