Quote:
Originally Posted by Jimjam
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Surely then, it would be like the Spanish Flu, where people with the 'best' immune systems were worst affected?
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Not necessarily. Covid inhibits type 1 interferon response and that's already impaired in the elderly.
https://www.nature.com/articles/s41591-020-01202-8
"A key feature of coronaviruses (MERS-CoV, SARS-CoV) is a capability to inhibit and delay the type I IFN response, leading to increased viral replication and severe immunopathology. Also, SARS-CoV-2 is able to inhibit the type I IFN responses in infected cells, leading to delayed or overall suppressed type I IFN responses49,50. This allows the virus to replicate and induce more tissue damage, and triggers a more exuberant immune response as the immune system struggles to limit viral replication and to manage dying and dead cells. Immune pathology continues as inflammatory cells flow into the lung and produce large amounts of proinflammatory cytokines, further escalating the situation (Fig. 1c). Such imbalanced immune responses, caused in part by the impaired early type I IFN responses, are the most likely determinant of the overall severity of acute COVID-19 (refs. 50,51,52,53). This is further emphasized by recent results from the COVID Human Genetic Effort54 (
https://www.covidhge.com/), which found that inborn errors in the type I IFN pathway55, or the presence of neutralizing autoantibodies to type I IFNs56, were strongly over-represented among individuals who developed life-threatening COVID-19. Whether imbalanced or impaired innate responses also contribute to the development of other disease manifestations such as MIS-C and long COVID remains to be determined."
05-04-2021, 02:10 PM
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