I had a z-heart on my necro for a bit. I would say that 1-48 it's pretty good as even Iksars get only 4 regen per tick sitting and you'll get beat up a decent bit charm soloing. Once you get Bond of Death, it's fairly cheap to heal up. And in a lot of cases the taps, with their -200 mod, are the best nukes you have anyway.
I just don't think it's possible to twink a caster in this era without focus items and non-raid FT and so on in comparison to a fungi melee.
I have used the beads a LOT though, both for healing up and riskless pulls (FD, send eye, FD, send eye, tag remainder).
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