Quote:
Originally Posted by Grizzler
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How do they have a biological basis for how they feel? Their chromosomes aren't some how different.
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A 2008 study compared 112 male-to-female transsexuals (both androphilic and gynephilic), mostly already undergoing hormone treatment, with 258 cisgender male controls. Male-to-female transsexuals were more likely than cisgender males to have a longer version of a receptor gene (longer repetitions of the gene) for the sex hormone androgen or testosterone, which reduced its effectiveness at binding testosterone.[3] The androgen receptor (NR3C4) is activated by the binding of testosterone or dihydrotestosterone, where it plays a critical role in the forming of primary and secondary male sex characteristics. The research suggests reduced androgen and androgen signaling contributes to the female gender identity of male-to-female transsexuals. The authors say that a decrease in testosterone levels in the brain during development might prevent complete masculinization of the brain in male-to-female transsexuals and thereby cause a more feminized brain and a female gender identity.
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https://en.wikipedia.org/wiki/Causes_of_transsexuality
Then again, apparently evidence of a biological basis actually causes bigots to be more bigoted, not less, so maybe I shouldn't have bothered with the above:
https://www.npr.org/sections/13.7/20...sis-for-gender