Okay, so, as someone who has just spent the last... 2 weeks on Nobles and Isabella, this is how you do them as a Necro.
Put on Manaskin, if avail.
Get down the hall near the dresser. Root first noble. Feign Death. Let the 2nd noble run back. Get up. The persisting root on Noble 1 wont pull Noble 2. Root Noble 2.
Splurt + Ignite Blood + Bond of Death to recharge health.
Noble 1 dies.
Splurt Noble 2.
Wait.
Splurt Noble 2.
Noble 2 dies (with a HUGE gap between his death and Noble 1's death, since your damage was all splurt).
Handle Isa the same way. Around 53-54, Isa turns LB/DB. The LB Isa just needs Splurt + Ignite Blood. You will need Spirit Tap (Level 29 Life Tap) to finish off DB targets.
From that point on, once the two nobles are spread out: Para Roots + Ignite Blood (first) + Splurt (2nd) + Bond of Death (3rd) on every one. The more the adds are spread out, the better, so you can maintain a good HP total throughout the 6 mins. This does not make it AFK friendly though.
Avoid FD while you have a target dotted, or they'll begin 5% health degen.
Just yesterday, I spent 15 and a half hours camping them. But hey, I got through 54.
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