I've found that, in general, if I get hit while quadding, it's either no big deal and I escape handily or I take a stun and I'm just dead. When I get the latter, I'm pretty sure the amount of hp items I would need to have lived would cripple my quadding ability in mana loss. Wish I had put my extra 5 in str, not sta.
To echo a lot of the above - have other stuff to do when you're soloing. Now that I'm on to Spirocs in the late 40s, my downtime is in excess of 10 minutes between pulls. I spend a lot of time folding laundry, doing dishes, playing with the kids, and that sort of stuff between pulls.
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