You can't alt tab without it going into windowed mode, and going back to full screen WILL crash the client eventually, so i recommend staying in windowed mode. But there are a few things you can do to make it at least work somewhat properly.
Check your options and make sure its running in the same resolution in windowed that you will want it running in full screen. If they are at different resolutions it will cause the mouse to either be restricted to a small area that = the window resolution, or it will just minimize the game when you click out of that area.
Then once you have launched the game alt+enter into windowed mode, and move the window around a little bit, then put it back into place and go back to full screen.
Now you should be able to Alt+Enter back into fullscreen and have no mouse issues. But like i said the client will crash on you eventually, its EQ.
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