I think your choice of classes will far outweigh the decision on whether or not to twink them.
I think the most important things are to:
1) be able to travel quickly
2) be able to dungeon crawl and see fun content along the way
3) have low downtime between fights
wizard/mage/cleric
druid/enchanter/warrior
druid/enchanter/monk
If you don't mind the travel or hybrid penalty there are obviously a lot of choices.
enchanter/any tank/cleric
cleric/rogue/tank
mage/necro/shaman
Just make sure you have some sort of heals and some sort of tanking ability and it should be fun.
I wouldn't underestimate the rage of having to wait 45 minutes for a boat though...
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