I use a Naga for all of my gaming, and I find a use for each key on every game. Only other mouse I use is my Deathadder for laptops.
Just as an example, I have my mouse assigned to all my weapons and offhands in GA, weapons and spy disguises in TF2, buildings in SC2, spells in EQ/WoW/LotRo, and almost all of my controls on BFBC2 are via mouse except movement
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