Yes, the regen is worth it.
The tradeoff is the low starting INT, which means a smaller mana pool, and the negative xp mod. The basic rule of thumb on Iksar regen is that it'll let you run the next-to-best mana conversion spell you have all the time without really losing much (if any) HP at all. Stack HP gear instead of INT and focus on turning HP into as many spells as you need.
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