Honestly, I feel like you twink a melee so that you don't feel absolutely miserable. I only felt I was more powerful than casters for the first 30-45 levels or so.
Casters may get less out of twinking but I think some underestimate the difference it can make and they have a far stronger starting point.
An FT1-item and Z-heart speeds up progression considerably. Simple +HP and +mana items can make fights basically unlosable.
The spell damage and dot clickies for casters are great too. E.g. wizard low level nuke wand, mage burned wood staff at 46 and VP staff for necro at 50. Perhaps for priest classes the clickies are more impactful however, e.g. lumi staff, jbb, sham epic.
Then there's utility items however like CoS will always be good for their respective classes.
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