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Originally Posted by greatdane
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There's not that much difference in damage between Bane and Ebolt, and Ebolt actually has a marginally better DPM. More importantly, Malo/sini doesn't reduce disease resist. If the goal is mana efficiency and not finishing the mob as fast as possible, it makes sense to forgo the disease dot. While Pox is slightly more DPM than the poison dots, it's not by much, and it gets resisted far more often. Nobody wants to devote a spell slot, mana and cast time to Insidious Decay. It's hard enough fitting in all the shit you need.
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The benefit of Pox is it gives you more time between recasts. This is the safer strategy on marathon mobs like Ionat who have high regen and can damage spike you unexpectedly even while slowed. You get more opportunities to Cannibalize/Torpor while waiting for your DoTs to clear. You can always apply a Bane in between if you have the extra mana. With a slowed mob you can sit right after they hit you and you'll have enough time to memorize a spell before they hit you if you need to swap out Insidious Decay.
Spamming Bane is the faster but riskier strategy, unless the mob is already easy. I haven't seen Pox get resisted "far more often" than poison. Poison gets resisted more from my experience. I imagine this is just RNG from both perspectives, unless someone can show some data about mob resists.