It depends on relation to what other cheaper items can do.
I wouldn't describe the difference between a Cloak of Flames and Silver Chitin Handwraps to be a "gamechanger" even if it's a strong upgrade. You probably wouldn't even notice the difference if no one told you they swapped the two.
Several items are too cheap to qualify since they fall below 10k in price, e.g. Jboots, cheap haste options, Solist's Icy wand, Singing Steel Helm, Deepwater Helm and other Kunark armor clickies.
Other items are too expensive to qualify, e.g. Fungi Tunic.
Some mentions from me are therefore,
JBB: Changes how you play a Shaman, at least during part of the leveling experience.
Fungi Staff: Similar to above.
CoS: Clicky invis is a bit of a novelty or niche thing but still think it qualifies
Lumi Staff: Similar to JBB
Ikky BP: If not too cheap to qualify still cuts downtime significantly for several classes.
Burnt Wood Staff: May also be too cheap to qualify but free nukes are great!
Blood Ember Greaves: Extra manafree FD. Huge!
Cobalt Bracer: May be too expensive for this list but shrink is BIG (heh) for big races.
Cobalt BP and Singing Steel BP: Invigor is nice if you can be arsed to click it!
Deepwater BP: Huge for paladins who got big bags full of jaspers!
I must have missed many many items but those are some that I can think of.
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