You're pushing it too hard and running conflicts with those leg days. Your body is struggling to maintain equilibrium.
I would train for cardio endurance. Unless you need sprints. You could easily benefit from an easier pace.
Your legs are huge so they will get tired easily. Is a 300lb leg press sufficient for what you gotta get through?
How much rest are u getting between when you push yourself? Test yourself? It takes a few days, even a week for muscles hit max readiness.
That is pretty crazy to hold up for 5 miles tho. Impressive!
I would settle into an 10 min pace slow as snails for anything over 3 tho. Unless I was running for my life.
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