There's those two giants in Frontier Mountains, but they're just boring XP, no loot. Similarly there's the frost giant elites in Great Divide that (basically) have no loot.
For some minimal loot (gems) you can instead do the geonids in wakening lands or (at 57 I think they're still blue?) the tar goos.
And if you really want loot, but don't care about faction, the
Per-Level Hunting Guide just reminded me about Kelethin guards.