I noticed that when i'm running EQ in window mode with multiple monitors, sometimes right click movement will continue to move my mouse (off screen) and when i release the pointer comes back is on a totally different monitor.
Regardless of the OS/use of wine, I think it more has to do with the following:
1. window mode or not
2. dpi settings on mouse
3. multiple or single monitors
4. background processes
5. limiting fps when not in window
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