Playing a P99 Bard (with /stopsong bindings) has been fine on my hands. You basically have a 3sec global cooldown for songs; compare that with World of Warcraft where you're spamming keypresses on 1-1.5sec abilities and often use combinations with modifier keys to bind 16+ abilities.
I don't know if it helps, but I put my song keybinds on 1,2,3,4,Q,E,R,T. Easy to reach everything with one hand while staying at WASD for movement. Most of my twists follow a nice easy pattern like 1-2-3 or Q-E-4 which utilize multiple fingers.
Full disclaimer I play at most in ~3 hour time windows. If you're playing EQ like it's your job, results may vary. I'm only in my 30's so wrist injuries could be just around the corner for me haha.
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[BLUE][59 Troubadour] Saisu (Wood Elf)
[GREEN][35 Warrior] Gruzzle (Dwarf)
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