One positive - there are certain quests that you can't do without beta neutral faction and it appears that the only way to raise that (if P99 has disabled the bloodstone HHK turn-in like live did ~ 2001ish) is to have a GM reset it for you. So, at least banker slayers may have a slight disadvantage if they ever want to do the staff of the wheel or incandescent armor quests etc.
-Mcoy
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