I use WASD or arrows in EQ (liberally switch between both setups during gameplay depending on whether or not I'm currently using the mouse etc).
On regular FPS I tend to use WASD just because changing any keys is a pain on modern games - there are like 30 different hotkeys and changing anything usually means you have to change a lot of other stuff as all handy keys are already assigned to something.
The only FPS I play on a regular basis where I don't use WASD is Quake Live (modern version of Quake 3), that is the only FPS I know that is so extreme as far as reaction time and eye-brain-muscle connection requirements are, that I can gain an advantage of using something different from WASD.
Therefore, on QL I use a special setup which is:
O - strafe right
I - strafe left
L - backpedal
RMB - forward
AltGr - jump
Try this setup. It's less taxing on your left hand tendons than WASD and therefore allows to get that little bit of extra performance out of your fingers. The very relaxed and natural hand position is probably also less prone to tendinitis / carpal long term than WASD.
Also, the problem with WASD is that W and S are activated by the same (middle) finger, that has to move between the keys before it can press it. That's a few extra 100ths of a second completely wasted, that will add up over time.
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