Thank you for clarifying!
You are correct, a casual player would probably be doing more like 100 damage per two seconds on average. However, I still think Call of Flame isn't worth the spell slot in most cases. You are spending 125 mana for 100 extra damage in those two seconds, using the aforementioned casual player. That is a terrible damage to mana ratio. After that, you still have to wait 18 seconds for the cooldown. That means the spell slot for Call of Flame is useless for a good portion of the fight.
Calefaction, as I stated before, can be useful if you need that extra burst damage to get yourself over the finish line. Due to it's recast time, however, it is only going to be usable a few times in the fight. It acts more like a Shadowknight's Harmtouch. It is useful in some situations where you need the burst damage, but it isn't really a cornerstone to build a strategy around in normal situations. You will still need to DPS the mob down using other methods for the majority of the fight, while you wait for Calefaction to recover. You are also spending 1/8 of your entire mana pool per cast, assuming you have 2000 mana. Hybrid mana pools tend to be lower. This leads me to believe Calefaction is highly inefficient for normal usage.
Now, I am not saying there are no situations where both spells may be useful. My first post was using the constraints you requested. Calefaction and Call of Flame have low casting times for damage spells. This is good. That means you could cast both at the start of a fight to get a good bit of burst damage out of the gate, and then recast them as necessary. This would bring a dangerous fight to a close faster. However, that strategy would only be useful if you are trying to kill a specific mob quickly. This is due to how much mana you are going to chew through. That initial burst of both spells is already 375 mana, which is roughly 1/5 of your 2000 mana. This strategy is not sustainable in normal situations, such as gaining experience or farming money.
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