If I am playing a class that can crowd control I would typically root/mez the green mob and kill the blue mob first simply because my spells have a higher chance of holding on the green mob instead of the blue mob.
If I'm not playing a root class I would probably burn down the lower mob ASAP.
If having to choose between attacking a caster or melee mob I will generally kill the caster first unless I'm an enchanter in which case I would mesmerize the caster.
Hope this helps.
-Sugz
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