[Nynian]

I have a technical question - for some reason today on the rogue I am having trouble holding a target. I target the mob and hit attack and nothing happens, I esc from the target - retarget and hit it a couple of times, then stop hitting it although its still in target and I'm in range. I esc, retarget and start hitting again. To actively fight I have to keep doing the esc and retarget thing. I've completely logged out and restarted computer, reloaded the latest patch and still have the same issues. Any ideas?