I play on a laptop so I use wasd to move and the arrows to look up/down/left/right. Alt+# for my spells with a instaclick item hotkeyed for chain casting. Have an action key set for selecting things I aim at or to open doors. Only use the track pad a little when I have to sort items.
Took a week to get used to but, I've got 2 toons to 60 playing this way and wouldn't go back to mouse.
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