Never take the faction hit from killing Velketor and you'll be able to roam the zone and kill freely, but that one is easy to avoid.
A lot of people don't tank their SG faction so they can stroll through to Western Wastes, but a lot of other people do tank it so they can farm SG. If you do tank it it's still possible to get through without a Succor while KOS.
Like Snyder said, not tanking Hole faction can have a few benefits but it's not a huge deal either way.
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