It doesn't make a world of difference tbh.
Using 1handers also makes sure you keep skills relevant for when you get epics.
I used a wurmslayer and lupine dagger until I got my swiftwind, circa 46. Earlier on I was using the silver swiftblade.
Once I had swiftwind I mixed up the wolf dagger and wurmslayer in primary as sitation dictated. Eventually I retired lupine dagger at 56. Wurmslayer was then used until 59. 59-60 I used primarily Earthcaller.
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