There is no golden answer. 1-50 its hard to beat Healer + Melee of basically any combination since Root sucks before Paralyzing Earth. There are lots of unconventional duos and trios that are super fun. I have been playing a lot of necromancer lately and one of my favorite partners is a Monk (shocking I know).
1-50 you can do whatever, hell I bet wiz/wiz wouldn't be as terrible as it sounds. 50-60 is where the meat hits the grinder. There are a lot of ways to get to 60, but the most common path is through Sebelis and Howling Stones. Both zones favor enchanters/clerics/shamans/monks/necromancers so these classes have an easier time hitting 60 than others.
One of the best groups I have been in was the other day we trio'd as Necro/Druid/Bard. Very unconventional group but it worked steller. Granted I am a superstar Necromancer so every group I am in is awesome
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