I use WSAD for movement. I remapped the surrounding keys to my frequently-used actions, so Q is my insta-clicky, E is assist, R toggles auto-run, T cycles targets, Y toggles sit/stand, G is pet guard, V is pet attack, X is duck, Z is spellbook, F targets nearest NPC, etc. That leaves my right hand free to use my Logitech gaming mouse, which has a few more hotkeys bound to its extra buttons.
I'm almost always charming and pulling, so my spell line-up looks like:
1 - pacify
2 - PBAE stun
3 - tash
4 - level 4 mez or a root
5 - slow (usually the level 24 50% slow, Tepid Deeds)
6 - long-duration mez (usually Dazzle or Entrance; GoK if fighting high-level mobs)
7 - charm (usually Allure)
8 - ToT or AE mem blur
Sometimes I'll load up a targeted AE mez or a second PBAE stun.
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