I dealt with this problem on my big screen it took me a while to figure it out. You have to have your monitor/tv resolution set to the same as your game. So if monitor is 1920x1080 FS has to be the same, or if you click outside of what it is set at you will click out of the game.
Honestly if you have 2 screens you should play in Windows mode because if you mouse over and click off screen you will most like die unless you are sitting.
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