Is his right-click broken completely, by chance? For instance, can he still mouse-look by right-clicking?
The reason I mention this is that my sister runs EQ on a Mac and had this problem when using the built-in trackpad. At first she thought it was just a problem with right-clicking merchants and then discovered that all right-click features were broken. She "solved" by using an external USB (or possibly bluetooth?) mouse instead of the laptop's built-in trackpad.
If that's the case, your uncle could try an external mouse if he's using a trackpad as well.
I do realize this doesn't explain the issue of being unable to give an NPC items, but it's the only suggestion that comes to mind.
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