Make sure you don't have Hardware-level Anti-aliasing, V-Sync etc on. Make sure all "3D Settings" are marked as "Use Application Settings." New cards don't like to play nice with the Titanium Client.
You should be able access these options by right-clicking on the desktop ----> personalize ---> display settings ---> advanced settings. Then enter the Nvidia Control Panel from one of the tabs on top.
Also try:
CNTRL-ALT-DELETE -----> Processes
Right click on EQ.exe (or Everquest.exe) and manually "set affinity" to to a single CPU core and see if that helps.
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