Fungi tunic and pre-nerf staff (if you are one of the lucky few who have one) are in a different ball park for twink items than anything else in my opinion. Beyond that just high end weapons make a big difference on any melee. Manastone is a big deal some classes.
Clickies can be a big deal such as Dmg Shield pots, red wood wands, root nets, sow pots etc. I know I have burned a great deal of mobs down with red wood wands, but the merchants so rarely get reset their usefulness is limited unless you want to start your session by spending 30 minutes buying garbage from a merchant.
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