There is a Felwithe faction that will be involved in your epic later on, so should be careful with that. Factions like neriak and cabilis will also make it easier to move about for the same reasons (there are kills in those zones involving your epic)
Honestly one of the great things about enchanters is being able to have the freedom to go anywhere. It's up to you but if you decide to kill some factions some of them will have no going back once done is done if you change your mind later.
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