Spirocs in TD are definitely the fastest and easiest quadding I've found so far. It does get crowded at times, though, which can be frustrating after the long trip out there.
Second to spirocs is the grassy area south of KC in DL. I found it to be great exp and pretty safe, unlike most of the rest of the area around KC. It's not hard to find mobs, and its accessibility can make it more appealing than TD.
Those are my top two quadding spots for mid 40s through early 50s; nothing else I tried (BW, various city guards, LOIO bloodgills) even came close.
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