[Itchybottom]

Originally Posted by Hasbinbad [You must be logged in to view images. Log in or Register.]

#1 theres a huge difference between hepatic overload and intoxication, and neither one happens with the first drink or so. If you start hydrating at this point, you shouldn't have any issues with a hangover.

There really isn't. There is a huge difference between hepatic FAILURE and intoxication, but overload is what happens when you've had a bit too much. Hydration, isn't all that causes a hang-over. Systemically, being drunk drops your blood insulin levels. In the blood, it's going to increase cholesterol, fibrinolysis and in turn increase the flow, which is going to backlog your liver and kidneys during the assault. Sodium intake and hydration are a key part of the puzzle, but they certainly aren't "it".

Originally Posted by Hasbinbad [You must be logged in to view images. Log in or Register.]

Elevated GGT levels are causative of hangovers now? Stop the press! How do you know such things? Also why would your large intestine begin secreting water after a couple drinks? That doesn't seem to make any sense. If this was true, everyone who ever went to college would have at least one story of how they had to go to the ER because they had water shooting out of their asses, and that they almost died from F&E imbalance..

Elevated GGT and AP levels are present when your liver can no longer process the ethanol. For the average person, that's 3 ounces of 40% abv ethanol per hour when the process starts.

Originally Posted by Hasbinbad [You must be logged in to view images. Log in or Register.]

You're ignoring the fact that the symptoms of a "hangover" are directly tied to fluid loss in the CNS rather than the general system of the body. Your brain gets pickled as the ETOH steals water, leaving salts. Of course fluids (at this late stage) would take some time to work, that system is fairly closed, and requires some time for the body to rehydrate.

I didn't ignore the fact that part of a hang-over is in part caused from dehydration. It certainly doesn't involve the central nervous system more than toxic filtration of your liver, and kidneys. As the alcohol levels in your blood elevates, your metabolic excretion slows down. Once you reach a certain point of with alcohol dehydrogenases - your acetaldehyde levels (via oxidization and free radicals) peak and your liver is no longer efficient. The central nervous system consists of your brain and spine -- and the only affect here in regards to it after too much to drink would be encephalitis.

Originally Posted by Hasbinbad [You must be logged in to view images. Log in or Register.]

Are you using "acute ethanol toxicity" as a euphamism for "drunk" or what?

Epidemiology term. I tried to dumb down my post so the layperson could understand most of it. It's a bit further than intoxicated, which is usually when you have a hang-over.

Originally Posted by Hasbinbad [You must be logged in to view images. Log in or Register.]

Getting drunk = cirrhosis now??

Hyper-vascular nodules form on the liver - as shown by ultrasound and dissection of rats when consuming over 6g/kg volume (with 10g/kg being the LD50.)

Originally Posted by Hasbinbad [You must be logged in to view images. Log in or Register.]

I think your liver will work just fine until you drink a half gallon of whiskey all at once or you spend several years drinking a pint of whiskey a day..
It produces everything it needs to produce, just might take a bit longer. Chronic ETOH abuse is really the bigger danger don't you think? I'm getting a bit of "the sky is falling" from your post man..

Chronic use is clearly more of a danger, but shocks to the liver with high consumption, are just as taxing due to cell recovery rate. The liver is a robust organ, but not quite as robust as the brain; once there is enough cumulative damage, it cannot regenerate itself due to blood flow issues. If someone were to consume a half gallon of whiskey, it would be largely up to their body weight and resting metabolic rate how it affected them. If you did this frequently, you would end up with not only chronic gastritis from the tissue irritating in your digestive tract, but you would also be lowering liver, kidney and pancreatic function. I was actually trying to insinuate higher volume than a half gallon though. I really meant binge drinking, which should be on topic since we are talking about idiots and Four-Loko here.

Originally Posted by Hasbinbad [You must be logged in to view images. Log in or Register.]

In all seriousness, please tell me how cipro affects autoimmune hepatitis in a positive manner.. I've heard a LOT about how cipro can CAUSE hepatitis, but nothing about how it cures it. Please explain.

It's rare for cipro to actually induce cholestatic hepatitis -- but it has happened before and to the general populace, it's not a problem.

Unfortunately when it comes to pharmaceuticals (just like product reviews) the negative effects often get more attention the longer the drug is used.

Flouroquinolones help clean the blood, when the liver is under stress and it inhibits cell division (gyrase). It's also super affective at being an RNA antiviral (which is what hepatitis is) In a regimen treating hepatitis, it is often used to treat the possibility of secondary infections in the body. Most studies indicate it's slope of effectiveness to drop after cirrhosis and hepatocellular carcinoma are present - but doctors of internal medicine still prescribe it even then, just in case. When it comes to the liver there is always the chance of bacterial peritonitis or hepatic encephalopathy and it's been shown to reduce that chance.

In the case of using it as part of the regimen to get rid of drunkenness, it's activity will help you by method of retarding topoisomerase (type II primarily, as it's practically a sharp shooter) enzyme production at the ligation step of the cell cycle. It's unknown why, but as a side-effect that somehow also decreases glucose repression rate which is one of the symptoms being drunk is causing.

I really hope I didn't get trolled here, and you just wanted to actually learn something, Hasbinbad.