Cocaine is great for curing a toothache. Coca tea is great for curing an upset stomach (works better than Alka-Selzter or bismuth, by far) and behaves similar to yerba mate as an afternoon pick-me-up. Acetaminophen makes opiates more dangerous than they actually are -- and they [opiates] react differently in the brain depending on if there is pain stimuli or not. The best delivery method for opiates is latex (opium) because you'll likely pass out before overdosing and killing yourself. The itch is what bothers me the most with opiates, which can be handled by chlorphenamine maleate (and as a bonus it can intensify the opioid reaction making it so you use less.)
Recreational use, cocaine is probably the only thing I'd consider in the long term. The high is so short that if it came down to it, you could be completely lucid without the clogged ears or tunnel vision in a matter of minutes. Everyone should have an LSD analogue (not actual LSD since most of you are probably unstable and it'd just draw out your anxieties more) once in their life in a nice calm environment too -- life is all about experiences and it certainly enables you to think differently. You'll want a sitter that isn't going to grill you with questions or be a buzzkill in general, and will just be there just in case.
That being said, I prefer to take Tramadol over Hydrocodone for the nerve damage in my heels, though I have refillable prescriptions for both. I hate having mind fog, and when it comes to most body highs associated with the favored drug here (cannabis) and MOST substances -- it feels like liver overload. I don't see a point in simulating half of the symptoms of hepatic encephalopathy for a recreational purpose; we're all going to die some day, and I don't think a preview showing is the smartest of ideas.
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