back in the days I used EZmacro to tradeskill.
macroing was illegal but I never afk macroed, just saved my arm from turning into jello
that, and placing stuff around your inventory and bags at the right place in the interface can reduce to amount of mouse work a lot, but still have to go trough the movements and the clicks. which is why ezmacro was usefull.
turned my brain to mush instead of my arm :P
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