Imagine if you will, someone who had genetic characteristics predisposed to make their bodies, accept estrogen and reject testosterone. IMO, and based on personal (and probably again more or less speculative) experience, because I am not a scientist or doctor, just a lay person who had a few labs done when they were suffering from these issues and lost in the world...
but it's not unheard of either in the trans community to find people very susceptible/compatible with estrogen, and others who's bodies reject it vehemently.
Everyone is different and HRT is one of those YMMV things.
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