If you're having trouble with the installation of Titanium itself, Loramin wrote a fantastic guide on how to install from an ISO that is hosted on the wiki, here:
Everquest Titanium Installation Guide
If you've managed to get past that, here's the instructions on how to set up the install so that it's ready for Project 1999:
Install Everquest Titanium to a fresh directory. This directory must be separate from any live Everquest installs and dedicated to EQEmulator. It is highly recommended you do not install Titanium to your program files folder if running Windows Vista/7/8.
DO NOT PATCH EVERQUEST, DO NOT RUN EVERQUEST.EXE OR EQGAME.EXE. If you patch your Titanium install you will need to uninstall and start over.
You must download the required Spell and File changes in order to play on Project 1999. You can find them here:
Project 1999 Spell Files (v31). Download and extract them into your Everquest directory.
Included in the spell files is Launch Titanium.bat - this is the file you will use to launch Everquest after you have completed the remaining steps. If you would like to create a shortcut, be sure it points to this file. You may right click launch titanium.bat and click send to desktop (Create shortcut) for easy shortcut creation.
Alternatively, right click eqgame.exe and click create shortcut. Right click your newly created shortcut, and in the target line add patchme to the end of the path, outside the quotes if they are present. Click OK.
The target line should look similar to this: "C:/program files/everquest/eqgame.exe" patchme
You may use this shortcut or Launch Titanium.bat to run everquest after you have completed installation.