Both are good choices but I would not choose either. The ruger is an excellent compact pistol, which is excellent for concealed carry, but if I can only hold 6+1 rounds, i would rather have something with 6 rounds and more stopping power like a 38 special revolver with a hidden hammer.
the 45 is a nice weapon for concealed carry if you get the right model/mods so that it doesn't have sharp pointy parts that will give out the conceal. the 45 will obs have a lot more kick then the 22 so your wife might tire from repeated fire.
in my CC weapons, i go for high stopping power and high capacity. my favorite so far has been BDA .380 and S&W 38 special model 49 aka the bodyguard
--edit--
gsorry, didnt really answer your question. if i had to choose one of those, would choose the 45 over the 380. more bullets, more power, more better
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