So, I can't comment about Wine because I tried using that and it went bad real quick...
My recommended alternative is what I did... I created a "Windows" hard drive using Parallels.
I run EQ on my Mac, and use Parallels v7.0 to create a 32 gig windows partition on my hard drive, then install EQ there natively just like you would on any windows box (EQ is pretty small after all at about 5Gig).
You can then run Parallels in coherence mode, and double click the EQ.exe to launch it in your windows environment. In coherence mode, the "windows" environment only shows you the active application windows running on the windows partition, but not the desktop background of windows etc.. so it looks "almost" native to being on your Mac.
This also gives you the option to install other things to a windows environment that you find useful as well, but do not have a native OS X client.
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