I've played a lot, I did not experience the wrist pain out of twisting many are bringing up - I think a lot of it is avoiding rapid double tapping, but instead slurring the key presses, and trying to spread the twist over whole hand to reduce binding on adjacent fingers.
For example, to twist 4 songs, I'd do
13
42
14
41
I rebound my assist hotkey to s, have tab set to toggle targets, r to closest mob, f to target self. To switch instruments, I set up a hotbar with a L shaped layout:
[main weapon]
[inventory spot][secondary]
Then I can kind of click through in a pattern to switch out weapon and instrument, or multiple instruments by holding one on my mouse - situationally, a hotkey with /autoinventory helps, as it both auto-equips or auto-inventories whatever you've got on your mouse, in that order.
I also off load my movement to the arrow keys, so there's not much going on with the other hand - making it easier to reach over and hit screenshot. In addition, if you rearrange your bags so they all tile, you can use the open/close all functions, which I rebound to ] and [.
Having your open inventory was something I did my entire career, and having that spot hotkey'd is also useful as it allows you to activate the many, many inventory items you will accumulate as a bard, and can quickly grab and swap from collection of open bags.
Hope this helps.
-Tork
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