[uygi]

Yeah, the OP question doesn't make much sense. I'm right-handed, but depending on what I'm doing I use either right or left hand for my direction keys- right hand if using hotkeys or straferunning, left hand if using mouse. How that couldn't just be reversed for a lefty is beyond me.

You can bind whatever keys to whatever other keys you want. You can do it through the client or whatever else, it really doesn't matter. What you can't do is create a looping/delay macro, or do anything that allows you to perform any kind of function without being at the computer. If you use the client, or 3rd party software, to bind your directional keys to some other button on your keyboard (or any other input device really...) nobody is going to care.

You can actually do quite a bit using key bindings and in-game macros, though my experience is that the Titanium client has some weird rules about what slots can be bound to keystrokes.