shift-clicking automatically chooses the whole stack. alt-left clicking an item pops up the item info (so you don't have to wait w/ the right click method). casting from a sitting position automatically makes you stand up. shift-up / shift-down lets you toggle through your previous chat box commands and tells. F1 targets yourself, F2 first group member, etc.
check out hot keys in the options menu for much more useful stuff (like opening all inventory bags, targeting last person to send you a tell, etc.)
/rewind can get you un-stuck from places like behind that stupid ladder in upper guk leading from the squire to the summoner
"/" is a shortcut for "/who". lots of other shortcuts for classes and names and zones. for example: typing "/ all c 49 60 oa" will give you a list of all un-anonymous clerics 49-60 in the oasis.
also, this one's a bit specific, but bard charm wipes the aggro/hate list on mobs -- excepting, of course, the hate generated from that charm itself. i'm not sure if this works with other class charms, but you can do some pretty cool stuff with this as a bard.
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